Polymer-Based Nanosystems—A Versatile Delivery Approach

Materials

Adelina-Gabriela Niculescu¹  Alexandru Mihai Grumezescu¹ 

[1] Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania;

关键词: polymer-based nanoparticles;    drug delivery;    targeted delivery;    vaccine delivery;    vaccine adjuvants;    novel nanocarriers;   

DOI  :  10.3390/ma14226812

来源: DOAJ

【 摘 要 】

Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.

【 授权许可】

Unknown