Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines

Journal of Nanobiotechnology

Review

关键词: Biodegradable;    nanoparticles;    polyesters;    vaccine delivery;    drug delivery;    gene delivery;   

DOI  :  10.1186/1477-3155-9-55

 received in 2011-09-27, accepted in 2011-11-28,  发布年份 2011

来源: Springer

【 摘 要 】

Biodegradable nanoparticles (NPs) are gaining increased attention for their ability to serve as a viable carrier for site specific delivery of vaccines, genes, drugs and other biomolecules in the body. They offer enhanced biocompatibility, superior drug/vaccine encapsulation, and convenient release profiles for a number of drugs, vaccines and biomolecules to be used in a variety of applications in the field of medicine. In this manuscript, the methods of preparation of biodegradable NPs, different factors affecting optimal drug encapsulation, factors affecting drug release rates, various surface modifications of nanoparticles to enhance in-vivo circulation, distribution and multimodal functionalities along with the specific applications such as tumor targeting, oral delivery, and delivery of these particles to the central nervous system have been reviewed.

【 授权许可】

CC BY   
© Mahapatro and Singh; licensee BioMed Central Ltd. 2011