Identifying rhesus macaque gene orthologs using heterospecific human CNV probes

Genomics Data

Sree Kanthaswamy¹  Blythe Durbin-Johnson²  Joseph N. Fass²  Jillian Ng³  David Glenn Smith³ 

[1] California National Primate Research Center, University of California, Davis, CA, USA;Genome Center Bioinformatics Core, University of California, Davis, CA, USA;Molecular Anthropology Laboratory, Department of Anthropology, University of California, Davis, CA, USA;

关键词: Macaca mulatta;    Copy number variation (CNV);    Homo sapiens;    Heterospecific sequence map;   

DOI  :  10.1016/j.gdata.2015.09.016

来源: DOAJ

【 摘 要 】

We used the Affymetrix® Genome-Wide Human SNP Array 6.0 to identify heterospecific markers and compare copy number and structural genomic variation between humans and rhesus macaques. Over 200,000 human copy number variation (CNV) probes were mapped to a Chinese and an Indian rhesus macaque sample. Observed genomic rearrangements and synteny were in agreement with the results of a previously published genomic comparison between humans and rhesus macaques. Comparisons between each of the two rhesus macaques and humans yielded 206 regions with copy numbers that differed by at least two fold in the Indian rhesus macaque and human, 32 in the Chinese rhesus macaque and human, and 147 in both rhesus macaques. The detailed genomic map and preliminary CNV data are useful for better understanding genetic variation in rhesus macaques, identifying derived changes in human CNVs that may have evolved by selection, and determining the suitability of rhesus macaques as human models for particular biomedical studies.

【 授权许可】

Unknown