CRISPR-Cas system: a potential alternative tool to cope antibiotic resistance

Antimicrobial Resistance and Infection Control

Zhongren Ma¹  Bilal Aslam¹  Zulqarnain Baloch¹  Derong Zhang¹  Maria Rasool²  Roman Farooq Alvi²  Muhammad Hidayat Rasool²  Mohsin Khurshid²  Saima Muzammil²  Adi Idris³ 

[1] Biomedical Research Center, Northwest Minzu University;Department of Microbiology, Government College University Faisalabad;Menzies Health Institute Queensland and School of Medical Science, Griffith University;

关键词: Antibiotic resistance;    CRISPR-Cas;   

DOI  :  10.1186/s13756-020-00795-6

来源: DOAJ

【 摘 要 】

Abstract Antibiotic exposure leads to massive selective pressures that initiate the emergence and spread of antibiotic resistance in commensal and pathogenic bacteria. The slow process of developing new antibiotics makes this approach counterintuitive for combatting the rapid emergence of new antibiotic resistant pathogens. Therefore, alternative approaches such as, the development of nucleic acid-based anti-bacterial treatments, anti-bacterial peptides, bacteriocins, anti-virulence compounds and bacteriophage therapies should be exploited to cope infections caused by resistant superbugs. In this editorial, we discuss how the newly popular CRISPR-Cas system has been applied to combat antibiotic resistance.

【 授权许可】

Unknown