Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative Diseases

Brain Sciences

Oriana Trubiani¹  Emanuela Mazzon²  Serena Silvestro²  Giovanni Schepici²  Placido Bramanti² 

[1] Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy;IRCCS Centro Neurolesi “Bonino-Pulejo,” Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy;

关键词: salivary biomarkers;    Alzheimer's disease;    Parkinson's disease;    amyotrophic lateral sclerosis;    multiple sclerosis;   

DOI  :  10.3390/brainsci10040245

来源: DOAJ

【 摘 要 】

Many neurological diseases are characterized by progressive neuronal degeneration. Early diagnosis and new markers are necessary for prompt therapeutic intervention. Several studies have aimed to identify biomarkers in different biological liquids. Furthermore, it is being considered whether saliva could be a potential biological sample for the investigation of neurodegenerative diseases. This work aims to provide an overview of the literature concerning biomarkers identified in saliva for the diagnosis of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Specifically, the studies have revealed that is possible to quantify beta-amyloid_1–42 and TAU protein from the saliva of AD patients. Instead, alpha-synuclein and protein deglycase (DJ-1) have been identified as new potential salivary biomarkers for the diagnosis of PD. Nevertheless, future studies will be needed to validate these salivary biomarkers in the diagnosis of neurological diseases.

【 授权许可】

Unknown