Nuclear transport, oxidative stress, and neurodegeneration

International Journal of Clinical and Experimental Pathology

Vivek P Patel¹  Charleen T Chu¹ 

关键词: Nuclear transport;    nuclear pore complex;    oxidative stress;    neurodegeneration;    Parkinson's disease;    Alzheimer's disease;    amyotrophic lateral sclerosis;    polyglutamine diseases;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Trafficking of transcription factors between the cytoplasm and the nucleus is an essential aspect of signal transduction, which is particularly challenging in neurons due to their highly polarized structure. Disruption in the subcellular localization of many proteins, including transcription factors, is observed in affected neurons of human neurodegenerative diseases. In these diseases, there is also growing evidence supporting alterations in nuclear transport as potential mechanisms underlying the observed mislocalization of proteins. Oxidative stress, which plays a key pathogenic role in these diseases, has also been associated with significant alterations in nuclear transport. After providing an overview of the major nuclear import and export pathways and discussing the impact of oxidative injury on nuclear trafficking of proteins, this review synthesizes emerging evidence for altered nuclear transport as a possible mechanism in the pathogenesis of neurodegenerative diseases. Potential strategies to overcome such deficits are also discussed.

【 授权许可】

Unknown