Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

Marine Drugs

Xiao-Long Yuan¹  Kuo Xu¹  and Xiao-Dong Li²  Chen Li² 

[1] Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China;Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China;

关键词: aspergillus;    metabolite;    marine;    alkaloid;    biological activity;   

DOI  :  10.3390/md18010054

来源: DOAJ

【 摘 要 】

Nitrogen heterocycles have drawn considerable attention due to of their significant biological activities. The marine fungi residing in extreme environments are among the richest sources of these basic nitrogen-containing secondary metabolites. As one of the most well-known universal groups of filamentous fungi, marine-derived Aspergillus species produce a large number of structurally unique heterocyclic alkaloids. This review attempts to provide a comprehensive summary of the structural diversity and biological activities of heterocyclic alkaloids that are produced by marine-derived Aspergillus species. Herein, a total of 130 such structures that were reported from the beginning of 2014 through the end of 2018 are included, and 75 references are cited in this review, which will benefit future drug development and innovation.

【 授权许可】

Unknown