Dietary Habits and Nutrition in Rheumatoid Arthritis: Can Diet Influence Disease Development and Clinical Manifestations?

Nutrients

MariaGrazia Tarsitano¹  Chiara Gioia²  Bruno Lucchino²  Manuela Di Franco²  Cristina Iannuccelli² 

[1] Dipartimento di Medicina Sperimentale, Sapienza University of Rome, 00161 Roma, Italy;Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari-Reumatologia, Sapienza University of Rome, 00161 Roma, Italy;

关键词: Rheumatoid Arthritis;    diet;    nutrition;    pathogenesis;    Mediterranean Diet;   

DOI  :  10.3390/nu12051456

来源: DOAJ

【 摘 要 】

Rheumatoid arthritis (RA) is a systemic, autoimmune disease characterized by joint involvement, with progressive cartilage and bone destruction. Genetic and environmental factors determine RA susceptibility. In recent years, an increasing number of studies suggested that diet has a central role in disease risk and progression. Several nutrients, such as polyunsaturated fatty acids, present anti-inflammatory and antioxidant properties, featuring a protective role for RA development, while others such as red meat and salt have a harmful effect. Gut microbiota alteration and body composition modifications are indirect mechanisms of how diet influences RA onset and progression. Possible protective effects of some dietary patterns and supplements, such as the Mediterranean Diet (MD), vitamin D and probiotics, could be a possible future adjunctive therapy to standard RA treatment. Therefore, a healthy lifestyle and nutrition have to be encouraged in patients with RA.

【 授权许可】

Unknown