The Cognitive‐Functional Composite is sensitive to clinical progression in early dementia: Longitudinal findings from the Catch‐Cog study cohort

Alzheimer’s & Dementia: Translational Research & Clinical Interventions

Sietske A.M. Sikkes¹  A.J. Brunner¹  Philip Scheltens¹  John E. Harrison¹  Roos J. Jutten¹  Craig W. Ritchie²  R.A.J. vanDeelen³  R. Vreeswijk³  Frank Jan de Jong⁴  Esther M. Opmeer⁵  André Aleman⁵ 

[1] Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience, Amsterdam Amsterdam UMC the Netherlands;Centre for Dementia Prevention University of Edinburgh Edinburgh UK;Department of Geriatrics Spaarne Gasthuis Haarlem the Netherlands;Department of Neurology Erasmus Medical Center Rotterdam the Netherlands;Department of Neurosciences University of Groningen University Medical Center Groningen Groningen the Netherlands;

关键词: Alzheimer's disease;    cognition;    dementia;    instrumental activities of daily living;    mild cognitive impairment;    outcome measures;   

DOI  :  10.1002/trc2.12020

来源: DOAJ

【 摘 要 】

Abstract Introduction In an attempt to capture clinically meaningful cognitive decline in early dementia, we developed the Cognitive‐Functional Composite (CFC). We investigated the CFC's sensitivity to decline in comparison to traditional clinical endpoints. Methods This longitudinal construct validation study included 148 participants with subjective cognitive decline, mild cognitive impairment, or mild dementia. The CFC and traditional tests were administered at baseline, 3, 6, and 12 months. Sensitivity to change was investigated using linear mixed models and r2 effect sizes. Results CFC scores declined over time (β = −.16, P < .001), with steepest decline observed in mild Alzheimer's dementia (β = −.25, P < .001). The CFC showed medium‐to‐large effect sizes at succeeding follow‐up points (r2 = .08‐.42), exhibiting greater change than the Clinical Dementia Rating scale (r2 = .02‐.12). Moreover, change on the CFC was significantly associated with informant reports of cognitive decline (β = .38, P < .001). Discussion By showing sensitivity to decline, the CFC could enhance the monitoring of disease progression in dementia research and clinical practice.

【 授权许可】

Unknown