Alzheimer's disease: relationship between cognitive aspects and power and coherence EEG measures

Arquivos de Neuro-Psiquiatria

Lineu C. Fonseca²  Gloria M.a.s. Tedrus²  Larissa R. Prandi¹  Adriana M. Almeida¹  Danilo S. Furlanetto¹ 

[1] ,Pontifícia Universidade Católica de Campinas Faculdade de Medicina Campinas SP ,Brazil

关键词: dementia;    cognition;    Alzheimer's disease;    electroencephalography;    demência;    cognição;    doença de Alzheimer;    eletroencefalograma;   

DOI  :  10.1590/S0004-282X2011000700005

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the relationship between specific cognitive aspects and quantitative EEG measures, in patients with mild or moderate Alzheimer's disease (AD). METHOD: Thirty-eight AD patients and 31 controls were assessed by CERAD neuropsychological battery (Consortium to Establish a Registry for AD) and the electroencephalogram (EEG). The absolute power and coherences EEG measures were calculated at rest. The correlations between the cognitive variables and the EEG were evaluated. RESULTS: In the AD group there were significant correlations between different coherence EEG measures and Mini-Mental State Examination, verbal fluency, modified Boston naming, word list memory with repetition, word list recall and recognition, and constructional praxis (p<0.01). These correlations were all negative for the delta and theta bands and positive for alpha and beta. There were no correlations between cognitive aspects and absolute EEG power. CONCLUSION: The coherence EEG measures reflect different forms in the relationship between regions related to various cognitive dysfunctions.

【 授权许可】

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