Neuro-biochemical changes induced by zinc oxide nanoparticles

Saudi Journal of Biological Sciences

Hossam M.A. Aljawdah¹  Marwa S.M. Diab²  Taghreed A. Hafiz³  Saleh Al-Quraishy⁴  Mohamed A. Dkhil⁴  Amira A. Bauomy⁴  Mutee Murshed⁵ 

[1] Corresponding author at: Department of Zoology, College of Science, King Saud University, Saudi Arabia.;Department of Zoology and Entomology, Faculty of Science, Helwan University, Egypt;Research (NODCAR), Egypt;Department of Zoology, College of Science, King Saud University, Saudi Arabia;;Molecular Drug Evaluation Department, National Organization for Drug Control &

关键词: Zinc oxide nanoparticles;    Brain monoamines;    Histopathology;    Oxidative stress;    DNA-fragmentation;    Mice;   

DOI  :  

来源: DOAJ

【 摘 要 】

Nanoparticles are now widely used in various aspects of life, especially zinc oxide nanoparticles (ZnNPs) that used in mouth washing, cosmetics, sunscreens, toothpaste and root canal flings. This research aims to determine the impact of ZnNPs on healthy mice's brain tissue. ZnNPs have caused major changes in the brain monoamines (dopamine, norepinephrine and serotonin) and ions such as Ca2+, Na+, K+ and Zn2+. Concerning the histological picture, administration of ZnNPs caused some histopathological impairment in brain tissue. In addition, ZnNPs reduced the level of glutathione and catalase in brain tissue, although an increase in the level of nitrite / nitrate and ROS was observed, while the level of malondialdhyde was not significantly altered. Moreover, ZnNPs induced DNA fragmentation in brain of mice. Collectively, the obtained results revealed that ZnNPs affected the brain levels of investigated monamines, ions, enzymatic and non-enzymatic antioxidants thus they may have potential influence on central nervous system.

【 授权许可】

Unknown