Evaluation of the effects of the green nanoparticles zinc oxide on monosodium glutamate-induced toxicity in the brain of rats

PeerJ

article

Reham Z. Hamza¹  Fawziah A. Al-Salmi²  Nahla S. El-Shenawy³ 

[1] Department of Zoology, Faculty of Science, Zagazig University;Department of Biology, Faculty of Science, Taif University;Department of Zoology, Faculty of Science, Suez Canal University

关键词: Zinc oxide nanoparticles;    Green synthesis;    Neurotransmitters;    MSG;    Cyclooxygenase-2;    Brain;    Brain biomarkers;    Acetylcholinesterase;    Histopathology;   

DOI  :  10.7717/peerj.7460

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundMonosodium glutamate (MSG) is used extensively as a food additive in the diets of many countries around the world.Aim of the studyOur aim was to determine the effects of green zinc oxide nanoparticles on MSG-induced oxidative damage, neurotransmitter changes, and histopathological alternation in the cerebral cortexes of rats.MethodsMSG was administered orally at two doses of 6 and 17.5 mg/kg body weight. The higher dose was associated with a significant decline in the activities of superoxide dismutase, catalase, and glutathione peroxidase, as well as the levels of brain-derived neurotrophic factor (BDNF) and glutathione (GSH) in the cerebral cortex of rats.ResultsThe administration of zinc oxide nanoparticles/green tea extract (ZnO NPs/GTE) to 17.5 mg/kg MSG-treated rats was associated with significant improvements in all parameters previously shown to be altered by MSG. The higher dose of MSG induced significant histopathological variation in brain tissue. Co-treatment of rats with ZnO NPs/GTE and MSG-HD inhibited the reduction of neurotransmitters and acetylcholinesterase by MSG.ConclusionsZnO NPs/GTE have the potential to protect against oxidative stress and neuronal necrosis induced by MSG-HD. ZnO NPs/GTE conferred a greater benefit than the control treatment or ZnO NPs or GTE administered separately.

【 授权许可】

CC BY