Bioactive Chemical Constituents from the Brown Alga Homoeostrichus formosana

International Journal of Molecular Sciences

Wei-Lung Wang¹  Shu-Fen Chiou²  Hui-Yu Fang²  Jyh-Horng Sheu²  Uvarani Chokkalingam²  Tsong-Long Hwang³  Shu-Li Chen⁴ 

[1] Department of Biology, National Changhua University of Education, Changhua 50007, Taiwan;Department of Marine Biotechnology and Resources, National Sun Yat-sen University,Kaohsiung 80424, Taiwan;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan;Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;

关键词: Homoeostrichus formosana;    chromenes;    cytotoxicity;    antibacterial;    anti-inflammatory;   

DOI  :  10.3390/ijms16010736

来源: DOAJ

【 摘 要 】

A new chromene derivative, 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-hydroxy-2,6-dimethyl-2H-chromene (1) together with four known natural products, methylfarnesylquinone (2), isololiolide (3), pheophytin a (4), and β-carotene (5) were isolated from the brownalga Homoeostrichus formosana. The structure of 1 was determined by extensive 1D and 2D spectroscopic analyses. Acetylation of 1 yielded the monoacetylated derivative2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-acetyl-2,6-dimethyl-2H-chromene (6). Compounds 1–6 exhibited various levels of cytotoxic, antibacterial, and anti-inflammatory activities. Compound 2 was found to display potent in vitro anti-inflammatory activity by inhibiting the generation of superoxide anion (IC50 0.22 ± 0.03 μg/mL) and elastase release(IC50 0.48 ± 0.11 μg/mL) in FMLP/CB-induced human neutrophils.

【 授权许可】

Unknown