Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis

Marine Drugs

Yongxin Li²  Ying Xu²  Lingli Liu²  Zhuang Han²  Pok Yui Lai²  Xiangrong Guo¹  Xixiang Zhang¹  Wenhan Lin³ 

[1] Advanced Nano-fabrication, Imaging & Characterization Core lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia;KAUST Global Collaborative Research, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China;State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China;

关键词: antibacterial;    cytotoxicity;    lipoamicoumacin;    Bacillus subtilis;   

DOI  :  10.3390/md10020319

来源: mdpi

【 摘 要 】

Four novel amicoumacins, namely lipoamicoumacins A–D (1–4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.