Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba

Molecules

Wei Zhang²  Jin-Feng Hu¹  Wen-Wen Lv²  Qing-Chun Zhao² 

[1] Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China

关键词: Litsea cubeba;    Lauraceae;    isoquinoline alkaloids;    antibacterial;    antifungal;    cytotoxicity;   

DOI  :  10.3390/molecules171112950

来源: mdpi

【 摘 要 】

Five novel isoquinoline alkaloids (+)-N-(methoxylcarbonyl)-N-nordicentrin (1), (+)-N-(methoxylcarbonyl)-N-norpredicentrine (2), (+)-N-(methoxylcarbonyl)-N-norbulbodione (3), and (+)-N-(methoxylcarbonyl)-N-norisocorydione (4), and (+)-8-methoxyisolaurenine-N-oxide (5) were isolated, together with one known compound, (+)-N-(methoxylcarbonyl)-N-norglaucine (6), from a 70% EtOH extract of the barks of Litsea cubeba. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D-NMR, IR, UV, and HRESIMS. Alkaloids 1, 2 and 6 showed antimicrobial activity against the bacterium S. aureus and two fungi (A. alternata and C. nicotianae). Compounds 3,4 exhibited significant cytotoxicity against all of six tested tumor cell lines.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.