The Roles of Glycans in Bladder Cancer

Frontiers in Oncology

Chunyan Xu¹  Lin Zhang¹  Shujing Wang¹  Yuli Jian¹  Zhongyang Xu¹  Xiaoxin Sun¹  Deyong Yang² 

[1] Department of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, China;Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, China;

关键词: glycans;    glycosyltransferases;    bladder cancer;    abnormal glycosylation;    biomarkers;   

DOI  :  10.3389/fonc.2020.00957

来源: DOAJ

【 摘 要 】

Bladder cancer is one of the most common malignant tumors of the urogenital system with high morbidity and mortality worldwide. Early diagnosis and personalized treatment are the keys to successful bladder cancer treatment. Due to high postoperative recurrence rates and poor prognosis, it is urgent to find suitable therapeutic targets and biomarkers. Glycans are one of the four biological macromolecules in the cells of an organism, along with proteins, nucleic acids, and lipids. Glycans play important roles in nascent peptide chain folding, protein processing, and translation, cell-to-cell adhesion, receptor-ligand recognition, and binding and cell signaling. Glycans are mainly divided into N-glycans, O-glycans, proteoglycans, and glycosphingolipids. The focus of this review is the discussion of glycans related to bladder cancer. Additionally, this review also addresses the clinical value of glycans in the diagnosis and treatment of bladder cancer. Abnormal glycans are likely to be potential biomarkers for bladder cancer.

【 授权许可】

Unknown