Molecular bases and clinical importance of the exceptional phenotypes of blood group P and PK

Revista Cubana de Hematología, Inmunología y Hemoterapia

de La Vega Elena, Daniel²  Hellberg, Asa¹  Chialina, Sergio²  Olsson, Martín²  Pivetta, Mario²  Solis, E²  Raillon, Miguel Ángel² 

[1] Hospital Universitario, Lund, Suecia;Laboratorio de Inmunohematología, Rosario, Argentina

关键词: blood group;    alloimmunization;    erythrocyte;    glycosyltransferases;    transfusion;    gestation;   

DOI  :  

学科分类：生理学与病理学

来源: SciELO

【 摘 要 】

All the cells of the individuals with phenotypes "p" y "Pk" lack the glucidic antigens of "public" blood groups. These subjects form natural and regular antibodies against the missing structures (anti-P, anti-PP1 y anti-PP1Pk) that agglutínate or hemolyze the red-blood cells of every individual, excepting those with the same phenotype. Due to the exceptional character of these pictures (a few individuals per million) and their association with severe transfusional hemolytic reactions and repeated miscarriages, these subjects should be identified and characterized.

【 授权许可】

CC BY-NC