Engineering probiotics as living diagnostics and therapeutics for improving human health

Microbial Cell Factories

Yajun Yan¹  Xiaolin Shen²  Qipeng Yuan²  Xinxiao Sun²  Jia Wang²  Huakang Sheng²  Zhao Zhou²  Xin Chen² 

[1] College of Engineering, The University of Georgia;State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology;

关键词: Probiotics;    Metabolic engineering;    Synthetic biology;    Microbiome;   

DOI  :  10.1186/s12934-020-01318-z

来源: DOAJ

【 摘 要 】

Abstract The gut microbiota that inhabit our gastrointestinal tract are well known to play an important role in maintaining human health in many aspects, including facilitating the digestion and absorption of nutrients, protecting against pathogens and regulating immune system. Gut microbiota dysbiosis is associated with a lot of diseases, such as inflammatory bowel disease, allergy, obesity, cardiovascular and neurodegenerative diseases and cancers. With the increasing knowledge of the microbiome, utilization of probiotic bacteria in modulating gut microbiota to prevent and treat a large number of disorders and diseases has gained much interest. In recent years, aided by the continuous development of tools and techniques, engineering probiotic microbes with desired characteristics and functionalities to benefit human health has made significant progress. In this paper, we summarize the recent advances in design and construction of probiotics as living diagnostics and therapeutics for probing and treating a series of diseases including metabolic disorders, inflammation and pathogenic bacteria infections. We also discuss the current challenges and future perspectives in expanding the application of probiotics for disease treatment and detection. We intend to provide insights and ideas for engineering of probiotics to better serve disease therapy and human health.

【 授权许可】

Unknown