Bistability in self-activating genes regulated by non-coding RNAs

3rd International Conference on Mathematical Modeling in Physical Sciences

物理学;数学

Miro-Bueno, Jesus^1

Research Institute of the IT4Innovations Centre of Excellence, Faculty of Philosophy and Science, Silesian University in Opava, Opava

74601, Czech Republic^1

关键词: Bio-molecular devices;    Genetic networks;    Non-coding RNAs;    Synthetic biology;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/574/1/012164/pdf
DOI  :  10.1088/1742-6596/574/1/012164

来源: IOP

【 摘 要 】

Non-coding RNA molecules are able to regulate gene expression and play an essential role in cells. On the other hand, bistability is an important behaviour of genetic networks. Here, we propose and study an ODE model in order to show how non-coding RNA can produce bistability in a simple way. The model comprises a single gene with positive feedback that is repressed by non-coding RNA molecules. We show how the values of all the reaction rates involved in the model are able to control the transitions between the high and low states. This new model can be interesting to clarify the role of non-coding RNA molecules in genetic networks. As well, these results can be interesting in synthetic biology for developing new genetic memories and biomolecular devices based on non-coding RNAs.