The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia

Frontiers in Cell and Developmental Biology

Hamed Shoorei¹  Atefe Abak²  Soudeh Ghafouri-Fard³  Mohammad Taheri⁵  Mahdi Mohaqiq⁶ 

[1] Department of Anatomical Sciences, Faculty of Medicine, Biranjd University of Medical Sciences, Birjand, Iran;Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;School of Advancement, Centennial College, Ashtonbee Campus, Toronto, ON, Canada;Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC, United States;

关键词: IGF;    miRNA;    lncRNA;    expression;    disorders;   

DOI  :  10.3389/fcell.2021.634512

来源: DOAJ

【 摘 要 】

The insulin-like growth factors (IGFs) are polypeptides with similar sequences with insulin. These factors regulate cell growth, development, maturation, and aging via different processes including the interplay with MAPK, Akt, and PI3K. IGF signaling participates in the pathogenesis of neoplasia, insulin resistance, diabetes mellitus, polycystic ovarian syndrome, cerebral ischemic injury, fatty liver disease, and several other conditions. Recent investigations have demonstrated the interplay between non-coding RNAs and IGF signaling. This interplay has fundamental roles in the development of the mentioned disorders. We designed the current study to search the available data about the role of IGF-associated non-coding RNAs in the evolution of neoplasia and other conditions. As novel therapeutic strategies have been designed for modification of IGF signaling, identification of the impact of non-coding RNAs in this pathway is necessary for the prediction of response to these modalities.

【 授权许可】

Unknown