The Emerging Role of Non-Coding RNAs in Osteoarthritis

Frontiers in Immunology

Mohammad Hallajnejad¹  Bashdar Mahmud Hussen²  Soudeh Ghafouri-Fard³  Afshin Taheriazam⁴  Christophe Poulet⁸  Michel Malaise⁸  Mohammad Taheri⁹  Atefe Abak^1,10 

[1] 0Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Center of Research and Strategic Studies, Lebanese French University, Erbil, Iraq;Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Orthopedics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran;Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq;Department of Rheumatology, University Hospital of Liège (CHULiege), Liège, Belgium;Fibropôle Research Group, University Hospital of Liège (CHULiege), Liège, Belgium;GIGA-I3 Research Group, GIGA Institute, University of Liège (ULiege) and University Hospital of Liège (CHULiege), Liège, Belgium;Institute of Human Genetics, Jena University Hospital, Jena, Germany;Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: lncRNA;    miRNA;    osteoarthritis;    ncRNAs;    expression;    circRNA;   

DOI  :  10.3389/fimmu.2021.773171

来源: DOAJ

【 摘 要 】

Osteoarthritis (OS) is the most frequent degenerative condition in the joints, disabling many adults. Several abnormalities in the articular cartilage, subchondral bone, synovial tissue, and meniscus have been detected in the course of OA. Destruction of articular cartilage, the formation of osteophytes, subchondral sclerosis, and hyperplasia of synovial tissue are hallmarks of OA. More recently, several investigations have underscored the regulatory roles of non-coding RNAs (ncRNAs) in OA development. Different classes of non-coding RNAs, including long ncRNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), have been reported to affect the development of OA. The expression level of these transcripts has also been used as diagnostic tools in OA. In the present article, we aimed at reporting the role of these transcripts in this process. We need to give a specific angle on the pathology to provide meaningful thoughts on it.

【 授权许可】

Unknown