Integrated genome sequencing and gene expression analysis in the Stroke-Prone Spontaneously Hypertensive Rat

QH426 Genetics

Dashti, Mohammed ; McBride, Martin

University:University of Glasgow

Department:Institute of Cardiovascular and Medical Sciences

关键词: Whole genome sequencing, NGS, microarray, bioinformatics, gene expression analysis, genetics, hypertension, stroke, heart failure, left ventricular hypertrophy, Stroke-Prone Spontaneously Hypertensive Rat, SHRSP, GWAS, miRNA;   

Others  :  http://theses.gla.ac.uk/6106/1/2014DashtiPhD.pdf

来源: University of Glasgow

【 摘 要 】

This research project attempts to identify the genetic determinants of SHRSP/Gla phenotypes by using mRNA and micro(mi)RNA expression profiling data, in combination with the genome sequence of the SHRSP/Gla and WKY/Gla, to facilitate human translational studies for hypertension and vice versa.