GH and IGF System: The Regulatory Role of miRNAs and lncRNAs in Cancer

Frontiers in Endocrinology

Chiara Sartori¹  Sabrina Angelini²  Maria E. Street³  Gloria Ravegnini³  Cecilia Catellani⁴ 

[1] Biotechnology, University of Bologna, Bologna, Italy;Department of Mother and Child, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy;;Department of Pharmacy &PhD Program in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy;

关键词: GH;    IGF;    miRNA;    lncRNA;    cancer;   

DOI  :  10.3389/fendo.2021.701246

来源: DOAJ

【 摘 要 】

Growth hormone (GH) and the insulin-like growth factor (IGF) system are involved in many biological processes and have growth-promoting actions regulating cell proliferation, differentiation, apoptosis and angiogenesis. A recent chapter in epigenetics is represented by microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) which regulate gene expression. Dysregulated miRNAs and lncRNAs have been associated with several diseases including cancer. Herein we report the most recent findings concerning miRNAs and lncRNAs regulating GH and the IGF system in the context of pituitary adenomas, osteosarcoma and colorectal cancer, shedding light on new possible therapeutic targets. Pituitary adenomas are increasingly common intracranial tumors and somatotroph adenomas determine supra-physiological GH secretion and cause acromegaly. Osteosarcoma is the most frequent bone tumor in children and adolescents and was reported in adults who were treated with GH in childhood. Colorectal cancer is the third cancer in the world and has a higher prevalence in acromegalic patients.

【 授权许可】

Unknown