Recent research progress on circular RNAs: Biogenesis, properties, functions, and therapeutic potential

Molecular Therapy: Nucleic Acids

Manojit Bhattacharya¹  Abinit Saha²  Sang-Soo Lee²  Swarnav Bhakta³  Ashish Ranjan Sharma⁴  Chiranjib Chakraborty⁴ 

[1] Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si 24252, Gangwon-do, Republic of Korea;Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat-Barrackpore Road, Jagannathpur, Kolkata, West Bengal 700126, India;Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore 756020, Odisha, India;;Institute for Skeletal Aging &

关键词: circular RNAs;    biogenesis;    properties;    therapeutic potential;   

DOI  :  

来源: DOAJ

【 摘 要 】

Circular RNAs (circRNAs), an emerging family member of RNAs, have gained importance in research due to their new functional roles in cellular physiology and disease progression. circRNAs are usually available in a wide range of cells and have shown tissue-specific expression as well as developmental specific expression. circRNAs are characterized by structural stability, conservation, and high abundance in the cell. In this review, we discuss the different models of biogenesis. The properties of circRNAs such as localization, structure and conserved pattern, stability, and expression specificity are also been illustrated. Furthermore, we discuss the biological functions of circRNAs such as microRNA (miRNA) sponging, cell cycle regulation, cell-to-cell communication, transcription regulation, translational regulation, disease diagnosis, and therapeutic potential. Finally, we discuss the recent research progress and future perspective of circRNAs. This review provides an understanding of potential diagnostic markers and the therapeutic potential of circRNAs, which are emerging daily.

【 授权许可】

Unknown