Pathogenic mechanisms and the potential clinical value of circFoxo3 in cancers

Molecular Therapy: Nucleic Acids

Yin Wang¹  Yuan Zhang²  Yanfang Zhao²  Lei Zhang²  Peifeng Li³ 

[1] Corresponding author: Lei Zhang, Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, NO38 DengZhou Road, Qingdao 266021, China.;Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, NO38 DengZhou Road, Qingdao 266021, China;Institute of Biomedical Research, School for Life Science, Shandong University of Technology, 266 Xincun West Road, Zibo 255000, China;

关键词: circular RNAs;    circFoxo3;    biogenesis;    action modes;    cancer pathogenesis;    clinical application;   

DOI  :  

来源: DOAJ

【 摘 要 】

Circular RNAs (circRNAs) are covalently closed circular structures that can function in various physiological and pathological processes by acting as microRNA (miRNA) sponges, RNA-binding protein (RBP) sponges, mRNA transcriptional regulators, and protein translational templates. circFoxo3 is one of the most studied circRNAs and is generated from the tumor suppressor gene Foxo3. Increasing studies have demonstrated the multiple functions of circFoxo3 in the pathogenesis of different cancer types. circFoxo3 plays important roles in cancer development mainly by binding to various miRNAs. The diagnostic potential of circFoxo3 has been revealed in several cancers. Some research results have been found to contradict the results of other studies, and this may be due to insufficient sample sizes and inconsistencies in the experimental and nomenclature methods. In this review, we systematically summarize current knowledge about the biogenesis and functions of circRNAs, elucidate the roles of circFoxo3 in different cancers, and explore the clinical applications of circFoxo3.

【 授权许可】

Unknown