Health Science Reports | |
Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population | |
Md. Shohel Hossain1  A. K. M. Jahirul Hossain Khan1  Md Sohel2  Md. Masudur Rahman3  Md. Shahadat Hossain3  Abhijit Das4  Mohammad Nurul Amin4  Jamiuddin Ahmed4  Mohammad Safiqul Islam4  Md. Monirul Islam5  Mst. Luthfun Nesa5  | |
[1] Armed Forces Food and Drugs Laboratory Dhaka Cantonment Dhaka Bangladesh;Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology University Tangail Bangladesh;Department of Pharmacy Atish Dipankar University of Science and Technology Dhaka Bangladesh;Department of Pharmacy Noakhali Science and Technology University Noakhali Bangladesh;Department of Pharmacy State University of Bangladesh Dhaka Bangladesh; | |
关键词: antioxidants; ESRD; lipid peroxidation; MDA; trace elements; | |
DOI : 10.1002/hsr2.348 | |
来源: DOAJ |
【 摘 要 】
Abstract Introduction End‐stage renal disease (ESRD) is an abnormality where the kidneys are not usually working. This case‐control study was planned to determine the extent of serum lipid peroxidation, non‐enzymatic antioxidant (vitamin c), and trace elements in 50 patients with ESRD as cases and 50 normal healthy individuals as controls. Methods Determination of lipid peroxidation was carried out by ascertaining concentration of malondialdehyde (MDA) and vitamin C in serum using UV spectrophotometry whereas atomic absorption spectroscopy was used for trace elements estimation. The statistical analysis was conducted via the independent t‐test samples and Pearson correlation test. Results The blood serum study has shown substantially higher MDA values than the control level and lowers vitamin C levels in the patient population (P < .001). A negative correlation was found between the vitamin C in serum with BMI and MDA for both patients (r = −0.017 and r = −0.132, respectively) and the control group (r = −0.014 and r = −0.229, respectively) after Pearson's correlation analysis. Regarding trace elements, significantly (P < .001) lower concentrations of zinc, copper, and manganese were found in the patient group than control subjects. Inter‐element‐relationship established a strong positive harmonization between these studied elements in both the cases of patients and control subjects. Conclusion Our results indicate strong associations of the pathogenesis of ESRD with depleted non‐enzymatic antioxidant, increased lipid peroxidation, and inconsistency in trace elements concentration in serum, which may provide a prognostic tool for the treatment of this concerning the disease.
【 授权许可】
Unknown