ATP‐synthase complex: The mechanism of control of ion fluxes induced by cumene hydroperoxide in mitochondria

FEBS Letters

Yaguzhinsky, L.S.¹  Goncharenko, E.N.²  Novgorodov, S.A.¹  Mohr, Yu.E.¹  Gudz, T.I.² 

[1]A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, Moscow 119899, USSR

[2]Department of Biophysics, Biological Faculty, Moscow State University, Moscow 119899, USSR

关键词: Mitochondria;    Ion transport;    Hydroperoxide;    BHT;    butylhydroxytoluene;    CuOOH;    cumene hydroperoxide;    TPP+;    tetraphenylphosphonium;    MDA;    malonic dialdehyde;    TBA;    2-thiobarbituric acid;    Δ;    ψ;    mitochondrial inner-membrane potential;    CATR;    carboxyatractyloside;    LP;    lipid peroxidation;   

DOI  :  10.1016/0014-5793(89)81347-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In state 4, the cumene hydroperoxide-induced decrease of mitochondrial transmembrane potential is prevented by the free radical scavenger, butylhydroxytoluene. This decrease is accompanied by accumulation of lipid hydroperoxides. Oligomycin suppresses the cumene hydroperoxide-induced uncoupling of mitochondria, but has no significant effect on lipid peroxidation. The transition of mitochondria from state 4 to state 3 by ADP addition leads to the suppression of both lipid peroxidation and mitochondrial uncoupling. This effect on lipid peroxidation is prevented by carboxyatractyloside and oligomycin.

【 授权许可】

Unknown