Autoinflammatory Mechanisms in Crystal-Induced Arthritis

Frontiers in Medicine

Eugen Feist¹  Anna Scanu²  Paolo Sfriso²  Sara Bindoli²  Francesca Oliviero²  Andrea Doria²  Paola Galozzi² 

[1] Department of Rheumatology, Cooperation Partner of the Otto-von-Guericke, University Magdeburg, Helios Clinic, Vogelsang-Gommern, Germany;Rheumatology Unit, Department of Medicine—DIMED, University of Padova, Padova, Italy;

关键词: crystal-induced arthritis;    interleukin-1;    autoinflammatory disease;    interleukin-1 receptor antagonist;    inflammasome;   

DOI  :  10.3389/fmed.2020.00166

来源: DOAJ

【 摘 要 】

Crystal-induced arthritides have been classified as “type-1 autoinflammatory diseases” for their main features which resemble those of the monogenic autoinflammatory syndromes. They are in fact characterized by spontaneous onset, recurrence of the episodes, self-limitation and resolution, inflammasome activation with huge production of IL-1β and a prevalent involvement of the innate immune system. The term “auto” refers also to the induction of IL-1β gene expression, processing and secretion by IL-1β itself. The concept of autoinflammation in crystal-induced arthritis has been finally reinforced by the efficacy of IL-1 blockade in treating acute and chronic state of this disease. The aim of this article is to review the autoinflammatory mechanisms in crystal-induced arthritis, considering both clinical and molecular aspects.

【 授权许可】

Unknown