Autoinflammatory Mechanisms in Crystal-Induced Arthritis

Frontiers in Medicine

article

Francesca Oliviero¹  Sara Bindoli¹  Anna Scanu¹  Eugen Feist²  Andrea Doria¹  Paola Galozzi¹  Paolo Sfriso¹ 

[1] Rheumatology Unit, Department of Medicine—DIMED, University of Padova;Department of Rheumatology, University Magdeburg, Helios Clinic

关键词: crystal-induced arthritis;    interleukin-1;    autoinflammatory disease;    interleukin-1 receptor antagonist;    inflammasome;   

DOI  :  10.3389/fmed.2020.00166

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Crystal-induced arthritides have been classified as “type-1 autoinflammatory diseases” for their main features which resemble those of the monogenic autoinflammatory syndromes. They are in fact characterized by spontaneous onset, recurrence of the episodes, self-limitation and resolution, inflammasome activation with huge production of IL-1β and a prevalent involvement of the innate immune system. The term “auto” refers also to the induction of IL-1β gene expression, processing and secretion by IL-1β itself. The concept of autoinflammation in crystal-induced arthritis has been finally reinforced by the efficacy of IL-1 blockade in treating acute and chronic state of this disease. The aim of this article is to review the autoinflammatory mechanisms in crystal-induced arthritis, considering both clinical and molecular aspects.

【 授权许可】

CC BY