Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

J. Svensson¹  C. Eckerström²  M. Eckerström²  M. Jonsson²  P. Kettunen² 

[1] Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg Sweden;Department of Psychiatry and Neurochemistry Sahlgrenska Academy Institute of Neuroscience and Physiology University of Gothenburg Sweden;

关键词: Alzheimer's disease;    cerebrospinal fluid biomarkers;    dementia;    diagnosis;    frontotemporal dementia;    Lewy body dementia;   

DOI  :  10.1002/dad2.12031

来源: DOAJ

【 摘 要 】

Abstract Introduction To evaluate the usefulness of the 2018 NIA‐AA (National Institute on Aging and Alzheimer's Association) research framework in a longitudinal memory clinic study with different clinical outcomes and underlying disorders. Methods We included 420 patients with mild cognitive impairment or subjective cognitive impairment. During the follow up, 27% of the patients converted to dementia, with the majority converting to Alzheimer's disease (AD) or mixed dementia. Based on the baseline values of the cerebrospinal fluid biomarkers, the patients were classified into one of the eight possible ATN groups (amyloid beta [Aβ] aggregation [A], tau aggregation reflecting neurofibrillary tangles [T], and neurodegeneration [N]). Results The majority of the patients converting to AD and mixed dementia were in ATN groups positive for A (71%). The A+T+N+ group was highly overrepresented among converters to AD and mixed dementia. Patients converting to dementias other than AD or mixed dementia were evenly distributed across the ATN groups Discussion Our findings provide support for the usefulness of the ATN system to detect incipient AD or mixed dementia.

【 授权许可】

Unknown