In Vitro Confirmation of Artemisinin Resistance in Plasmodium falciparum from Patient Isolates, Southern Rwanda, 2019

Emerging Infectious Diseases

关键词: malaria;    Plasmodium falciparum;    artemisinin resistance;    antimicrobial resistance;    Kelch-13 gene mutations;    parasites;   

DOI  :  10.3201/eid2804.212269

来源: DOAJ

【 摘 要 】

Artemisinin resistance in Plasmodium falciparum is conferred by mutations in the kelch 13 (K13) gene. In Rwanda, K13 mutations have increased over the past decade, including mutations associated with delayed parasite clearance. We document artemisinin resistance in P. falciparum patient isolates from Rwanda carrying K13 R561H, A675V, and C469F mutations.

【 授权许可】

Unknown