Fluoroquinolone antimicrobial resistance of Escherichia coli isolated from swine feces in Korea

quinolone;fluoroquinolone;antimicrobial resistance;Escherichia coli;pig;636

수의과대학 수의학과 ;

University:서울대학교 대학원

关键词: quinolone;    fluoroquinolone;    antimicrobial resistance;    Escherichia coli;    pig;    636;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/133773/1/000000140963.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

of these 59 isolates, 58 had mutations in parC (98.3%), 22 had mutations in parE (37.3%), and none had mutations in gyrB. The predominant mutation was Ser83Leu in gyrA, followed by Ser80Ile in parC, and Ser458Ala in parE. Nine isolates harbored PMQR genes, including qnrS (n = 7, 11.9%), qepA (n = 1, 1.7%), and aac(6’)-Ib-cr (n = 1, 1.7%). Efflux pump activity was found in 56 isolates (94.9%). FQ-resistant E. coli had high minimum inhibitory concentrations against CIP, and most isolates were multidrug-resistant. Compared with previous studies in Korea, the prevalence of FQ resistance and PMQR genes had increased significantly in swine. Although the use of FQ as a feed additives is prohibited in Korea, use for self-treatment and therapeutic purposes has been increasing, which may be responsible for the higher FQ-resistance rate observed in this study. Therefore, prudent use of FQ in animal farms is needed to reduce the evolution of FQ-resistant bacteria in Korea.