Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

Frontiers in Chemistry

Qi Tan¹  Yan Chen¹  Ge Zou¹  Wencong Yang²  Yilin Yuan²  Wenyi Kang³  Guisheng Wang³  Zhigang She³ 

[1] D Center for Edible Fungus Processing Technology, Henan University, Kaifeng, China;;National R &School of Chemistry, Sun Yat-sen University, Guangzhou, China;

关键词: mangrove;    endophytic fungus;    Fusarium sp.;    cytotoxicity;    benzofuran;    chromone;   

DOI  :  10.3389/fchem.2022.842405

来源: DOAJ

【 摘 要 】

Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one new chromone fusarimone A (5), two new benzofurans fusarifurans A (9) and B (10), three new isocoumarins fusarimarins A–C (11–13), as well as five known analogues 3, 4, 6–8 and 14 were isolated from mangrove endophytic fungus Fusarium sp. 2ST2. Their structures and absolute configurations were established by spectroscopic analysis, density functional theory-gauge invariant atomic orbital NMR calculation with DP4+ statistical analysis, and electronic circular dichroism calculation. Compounds 1 and 2 showed significant cytotoxicity against human A549 cell lines with IC50 values of 8.7 and 4.3 μM, respectively.

【 授权许可】

Unknown