Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae

Marine Drugs

BlessingO. Umeokoli¹  Zhiyong Guo²  Kun Zou²  Dieter Meier³  Xiaoqin Yu³  Zhen Liu³  Rainer Kalscheuer³  Peter Proksch³  WernerE. G. Müller⁴ 

[1] Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, 420281 Awka, Nigeria;Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China;Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Duesseldorf, 40225 Duesseldorf, Germany;Institute of Physiological Chemistry, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, 55128 Mainz, Germany;

关键词: pseudopestalotiopsis theae;    endophytic fungus;    polyketide;    cytotoxicity;   

DOI  :  10.3390/md18020129

来源: DOAJ

【 摘 要 】

Chemical investigation of secondary metabolites from the endophytic fungus Pseudopestalotiopsis theae led to the isolation of eighteen new polyketide derivatives, pestalotheols I−Q (1−9) and cytosporins O−W (15−23), together with eight known analogs (10−14 and 24−26). The structures of the new compounds were elucidated by HRMS and 1D and 2D NMR data, as well as by comparison with literature data. Modified Mosher’s method was applied to determine the absolute configuration of some compounds. Compound 23 showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with an IC₅₀ value of 3.0 μM. Furthermore, compounds 22 and 23 showed moderate antibacterial activity against drug-resistant Acinetobacter baumannii (ATCC BAA-1605) in combination with sublethal colistin concentrations.

【 授权许可】

Unknown