Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea

Marine Drugs

Cai-Huan Huang¹  Jia-Hui Pan¹  Bin Chen¹  Miao Yu²  Hong-Bo Huang¹  Xun Zhu⁴  Yong-Jun Lu³  Zhi-Gang She¹ 

[1] School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China; E-Mails:;School of Science and Engineering, Jinan University, Guangzhou 510632, China; E-Mail:;School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China; E-Mail:;Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, China; E-Mail:

关键词: endophytic fungus;    Alternaria sp.;    bianthraquinone;    alterporriol;    cytotoxicity;   

DOI  :  10.3390/md9050832

来源: mdpi

【 摘 要 】

Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC₅₀ values ranging from 13.1 to 29.1 μM.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.