Alterporriol-Type Dimers from the Mangrove Endophytic Fungus, Alternaria sp. (SK11), and Their MptpB Inhibitions

Marine Drugs

Guoping Xia²  Jia Li²  Hanxiang Li²  Yuhua Long³  Shao𠆞 Lin²  Yongjun Lu¹  Lei He¹  Yongcheng Lin²  Lan Liu² 

[1] School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China; E-Mails:;School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China; E-Mails:;School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China; E-Mail:

关键词: endophytic fungus;    Alternaria sp.;    alterporriol;    theoretical calculations;    ECD;    TDDFT;    MptpB;   

DOI  :  10.3390/md12052953

来源: mdpi

【 摘 要 】

A new alterporriol-type anthranoid dimer, alterporriol S (1), along with seven known anthraquinone derivatives, (+)-aS-alterporriol C (2), hydroxybostrycin (3), halorosellinia A (4), tetrahydrobostrycin (5), 9α-hydroxydihydrodesoxybostrycin (6), austrocortinin (7) and 6-methylquinizarin (8), were isolated from the culture broth of the mangrove fungus, Alternaria sp. (SK11), from the South China Sea. Their structures and the relative configurations were elucidated using comprehensive spectroscopic methods, including 1D and 2D NMR spectra. The absolute configurations of 1 and the axial configuration of 2 were defined by experimental and theoretical ECD spectroscopy. 1 was identified as the first member of alterporriols consisting of a unique C-10−C-2′ linkage. Atropisomer 2 exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with an IC₅₀ value 8.70 μM.

【 授权许可】

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