Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.

Marine Drugs

Jinhua Wang²  Daniel G. Cox³  Weijia Ding²  Guanghao Huang²  Yongcheng Lin¹ 

[1] School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China; E-Mail:;Institute of Biomaterial, College of Science, South China Agricultural University, Guangzhou 510642, China; E-Mails:;Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, Mississippi University, Oxford, MS 38677, USA; E-Mail:

关键词: marine fungus;    Alternaria sp.;    mangrove;    stilbenes;    resveratrol;    antioxidant;    antitumor;   

DOI  :  10.3390/md12052840

来源: mdpi

【 摘 要 】

Three new resveratrol derivatives, namely, resveratrodehydes A–C (1–3), were isolated from the mangrove endophytic fungus Alternaria sp. R6. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. All compounds showed broad-spectrum inhibitory activities against three human cancer cell lines including human breast MDA-MB-435, human liver HepG2, and human colon HCT-116 by MTT assay (IC₅₀ < 50 μM). Among them, compounds 1 and 2 both exhibited marked cytotoxic activities against MDA-MB-435 and HCT-116 cell lines (IC₅₀ < 10 μM). Additionally, compounds 1 and 3 showed moderate antioxidant activity by DPPH radical scavenging assay.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.