Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321

Marine Drugs

Yongxiang Song²  Jiajian Wang²  Hongbo Huang²  Lin Ma²  Jun Wang³  Yucheng Gu¹  Lan Liu² 

[1] Syngenta Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK;School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China;Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-Sen University), Bureau of Education of Guangdong, Guangzhou, 510275, China;

关键词: marine fungus;    Xylaria sp.;    mangrove;    sesquiterpenes;    α-glucosidase;   

DOI  :  10.3390/md10020340

来源: mdpi

【 摘 要 】

Three new eremophilane sesquiterpenes (1–3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC₅₀ value is 6.54 μM.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.