Effect of Culture Conditions on Metabolite Production of Xylaria sp.

Molecules

Hongqi Zhang¹  Zhangshuang Deng¹  Zhiyong Guo¹  Yan Peng²  Nianyu Huang¹  Haibo He¹  Xuan Tu¹  Kun Zou¹ 

[1] Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China; E-Mails:;The First College of Clinical Medical Science, China Three Gorges University, Yichang 443002, China; E-Mail:

关键词: Xylaria sp.;    cryptic natural product;    cytochalasin;    α-pyrone;    xylapyrones;    cytotoxicity;   

DOI  :  10.3390/molecules20057940

来源: mdpi

【 摘 要 】

Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated. A shift in the production of five known cytochalasin-type analogues 1–5 to six new α-pyrone derivatives, xylapyrones A–F (compounds 6–11), from a solid to a liquid medium was observed. These compounds were identified by analysis of 1D and 2D NMR and HRMS data. Compounds 1–3 showed moderate cytotoxicity against HepG2 and Caski cancer cell lines with IC₅₀ values ranging from 25 to 63 μM and compounds 4–11 were found to be inactive, with IC₅₀ values >100 μM.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.