Nocapyrones: α- and γ-Pyrones from a Marine-Derived Nocardiopsis sp.

Marine Drugs

Youngju Kim¹  Hiromu Ogura¹  Kazuaki Akasaka³  Tsutomu Oikawa²  Nobuyasu Matsuura⁵  Chiaki Imada⁶  Hisato Yasuda⁴ 

[1] Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan; E-Mails:;School of Nutrition and Dietetics, Kanagawa University of Human Services, 1-10-1 Heisei-cho, Yokosuka, Kanagawa 238-8566, Japan; E-Mail:;Shokei Gakuin University, 4-10-1 Yurigaoka, Natori, Miyagi 981-1295, Japan; E-Mail:;Center for Advanced Marine Core Research, Kochi University, B200 Monobe, Nankoku, Kochi 783-8502, Japan; E-Mail:;Okayama University of Science, 1-1 Ridai-cho, Okayama, Okayama 700-0005, Japan; E-Mail:;Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan; E-Mail:

关键词: adiponectin;    adipocyte;    α-pyrone;    γ-pyrone;    Nocardiopsis;   

DOI  :  10.3390/md12074110

来源: mdpi

【 摘 要 】

One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2–4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2–4 were found to induce adiponectin production in murine ST-13 preadipocyte cells but the α-pyrone 1 had no activity. The absolute configuration of the anteiso-methyl branching in 4 was determined by HPLC comparison of a degraded product of 4 with standard samples as a 2:3 enantiomeric mixture of (R)- and (S)-isomers.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.