期刊论文详细信息
Marine Drugs 卷:12
Nocapyrones: α- and γ-Pyrones from a Marine-Derived Nocardiopsis sp.
Yasuhiro Igarashi1  Hiromu Ogura1  Youngju Kim1  Hisato Yasuda2  Nobuyasu Matsuura3  Tsutomu Oikawa4  Kazuaki Akasaka5  Chiaki Imada6 
[1] Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan;
[2] Center for Advanced Marine Core Research, Kochi University, B200 Monobe, Nankoku,Kochi 783-8502, Japan;
[3] Okayama University of Science, 1-1 Ridai-cho, Okayama, Okayama 700-0005, Japan;
[4] School of Nutrition and Dietetics, Kanagawa University of Human Services, 1-10-1 Heisei-cho, Yokosuka, Kanagawa 238-8566, Japan;
[5] Shokei Gakuin University, 4-10-1 Yurigaoka, Natori, Miyagi 981-1295, Japan;
[6] Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku,Tokyo 108-8477, Japan;
关键词: adiponectin;    adipocyte;    α-pyrone;    γ-pyrone;    Nocardiopsis;   
DOI  :  10.3390/md12074110
来源: DOAJ
【 摘 要 】

One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones(nocapyrones B, H and L (2–4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2–4 were found to induce adiponectin production in murine ST-13 preadipocyte cells but the α-pyrone 1 had no activity. The absolute configuration of the anteiso-methyl branching in 4 was determined by HPLC comparison of a degraded product of 4 with standard samples as a 2:3 enantiomeric mixture of (R)- and (S)-isomers.

【 授权许可】

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