Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate

Molecules

Ting Lin¹  Guang Hui Wang¹  Xiang Lin¹  Zhi Yu Hu¹  Quan Cheng Chen¹  Yang Xu¹  Xiao Kun Zhang¹ 

[1] ¹School of Pharmaceutical Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China

关键词: Camptotheca acuminate;    endophytic fungus;    Phomopsis sp. XZ-01;    oblongolides;    new metabolites;   

DOI  :  10.3390/molecules16043351

来源: mdpi

【 摘 要 】

Four new metabolites, including three new oblongolides named C1, P1, and X1 (1-3) and 6-hydroxyphomodiol (10), along with eight known compounds – oblongolides B (4), C (5), D (6), O (7), P (8) and U (9), (3R,4aR,5S,6R)-6-hydroxy-5-methylramulosin (11), and (3R)-5-methylmellein (12) – were isolated from the endophytic fungal strain Phomopsis sp. XZ-01 of Camptotheca acuminate. Their structures were elucidated by spectroscopic analyses, including ¹H- and ¹³C-NMR, 2D NMR (HSQC, HMBC, ¹H-¹H COSY and NOESY) and HR-FT-MS. Cytotoxic activities of these compounds were evaluated. Some of them showed weak selective activities.

【 授权许可】

CC BY   
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