New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius

Marine Drugs

Zhi-Qiang Bai¹  Xiuping Lin¹  Junfeng Wang¹  Xuefeng Zhou¹  Juan Liu¹  Bin Yang¹  Xianwen Yang¹  Shengrong Liao¹  Lishu Wang²  Yonghong Liu¹ 

[1] Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; E-Mails:;Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, China; E-Mail:

关键词: meroterpenoid;    Aspergillus flavipes;    endophytic fungus;   

DOI  :  10.3390/md13010237

来源: mdpi

【 摘 要 】

Four new meroterpenoids (2–5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1–7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities.

【 授权许可】

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