New Bergamotane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense

Molecules

Zhe Guo¹  Fengxia Ren²  Yongsheng Che²  Gang Liu¹  Ling Liu¹ 

[1] State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China; E-Mail:;State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China; E-Mails:

关键词: Paraconiothynium brasiliense;    endophytic fungus;    sesquiterpenoid;   

DOI  :  10.3390/molecules200814611

来源: mdpi

【 摘 要 】

Brasilamides K-N (1–4), four new bergamotane sesquiterpenoids; with 4-oxatricyclo (3.3.1.0 ^2,7)nonane (1)and 9-oxatricyclo(4.3.0.0 ^4,7)nonane (2–4) skeletons; were isolated from the scale-up fermentation cultures of the plant endophytic fungus Paraconiothynium brasiliense Verkley. The previously identified sesquiterpenoids brasilamides A and C (5 and 6) were also reisolated in the current work. The structures of 1–4 were elucidated primarily by interpretation of NMR spectroscopic data. The absolute configurations of 1–3 were deduced by analogy to the co-isolated metabolites 5 and 6; whereas that of C-12 in 4 was assigned using the modified Mosher method. The cytotoxicity of all compounds against a panel of eight human tumor cell lines were assayed.

【 授权许可】

CC BY   
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