Anti-Inflammatory Components from the Root of Solanum erianthum

International Journal of Molecular Sciences

Yu-Chang Chen²  Hong-Zin Lee³  Hsin-Chun Chen⁴  Chi-Luan Wen¹  Yueh-Hsiung Kuo² 

[1] Taiwan Seed Improvement and Propagation Station, Council of Agriculture, Taichung 426, Taiwan; E-Mail:;Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan; E-Mail:;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; E-Mail:;Department of Cosmeceutics, China Medical University, Taichung 404, Taiwan; E-Mail:

关键词: Solanum erianthum;    Solanaceae;    root;    solanerianone;    norsesquiterpenoid;    sesquiterpenoid;    spirovetivene;    anti-inflammatory;    cytotoxicity;   

DOI  :  10.3390/ijms140612581

来源: mdpi

【 摘 要 】

Two new norsesquiterpenoids, solanerianones A and B (1–2), together with nine known compounds, including four sesquiterpenoids, (−)-solavetivone (3), (+)-anhydro-β-rotunol (4), solafuranone (5), lycifuranone A (6); one alkaloid, N-trans-feruloyltyramine (7); one fatty acid, palmitic acid (8); one phenylalkanoid, acetovanillone (9), and two steroids, β-sitosterol (10) and stigmasterol (11) were isolated from the n-hexane-soluble part of the roots of Solanum erianthum. Their structures were elucidated on the basis of physical and spectroscopic data analyses. The anti-inflammatory activity of these isolates was monitored by nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells. The cytotoxicity towards human lung squamous carcinoma (CH27), human hepatocellular carcinoma (Hep 3B), human oral squamous carcinoma (HSC-3) and human melanoma (M21) cell lines was also screened by using an MTT assay. Of the compounds tested, 3 exhibited the strongest NO inhibition with the average maximum inhibition (E_max) at 100 μM and median inhibitory concentration (IC₅₀) values of 98.23% ± 0.08% and 65.54 ± 0.18 μM, respectively. None of compounds (1–9) was found to possess cytotoxic activity against human cancer cell lines at concentrations up to 30 μM.

【 授权许可】

CC BY   
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