Caavuranamide, a novel steroidal alkaloid from the ripe fruits of Solanum caavurana Vell. (Solanaceae)

Journal of the Brazilian Chemical Society

Ruiz, Ana Lúcia T. G.¹  Universidade Federal de Sergipe, São Cristovão, Brazil¹  Maia, Beatriz H. L. N. Sales¹  Souza, Vanessa H. S.¹  Embrapa Florestas, Colombo, Brazil¹  Braga, Raquel M.¹  Vaz, Nelissa Pacheco¹  Delarmelina, Camila¹  Costa, Emmanoel V.¹  Duarte, Marta C. T.¹  Mikich, Sandra Bos¹  Universidade Estadual de Campinas, Campinas, Brazil¹  Marques, Francisco A.¹  Santos, Érica L.¹  Carvalho, João E. de¹  Universidade Federal do Paraná, Curitiba, Brazil¹ 

关键词: Solanum caavurana;    Solanaceae;    caavuranamide;    steroidal alkaloids;    spirosolane;   

DOI  :  10.1590/S0103-50532012000200025

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Phytochemical investigation of the ripe fruits of Solanum caavurana Vell. (Solanaceae) afforded a novel steroidal alkaloid with spirosolane-type skeleton, named as caavuranamide, together with the alkaloids 4-tomatiden-3-one and 5α-tomatidan-3-one. Their structures were elucidated on the basis of spectroscopic methods. The antiproliferative and antimicrobial activities for the ethanolic extract, sub-fractions obtained from partition and acid-base treatment were also evaluated. Caavuranamide showed antibacterial activity similar to the chloramphenicol positive control against Rhodococcus equi.

【 授权许可】

Unknown