C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog

Beilstein Journal of Organic Chemistry

Philipp Heretsch¹  Sebastian Rabe²  Johann Moschner²  Marina Bantzi²  Athanassios Giannis² 

[1] Rice University, Department of Chemistry, BioScience Research Collaborative, 6100 Main St., Houston, Texas 77005, United States;Universität Leipzig, Institut für Organische Chemie, Johannisallee 29, D-04103 Leipzig, Germany;

关键词: cyclopamine;    C–H-functionalization;    hedgehog signaling pathway;    natural products;    steroidal alkaloids;   

DOI  :  10.3762/bjoc.10.161

来源: DOAJ

【 摘 要 】

The chemical synthesis of carbacyclopamine analog 2, a cyclopamine analog with an all-carbon E-ring, is reported. The use of C–H-functionalization logic and further metal-catalyzed transformations allows for a concise entry to this new class of acid-stable cyclopamine analogs.

【 授权许可】

Unknown