Caavuranamide, a novel steroidal alkaloid from the ripe fruits of Solanum caavurana Vell. (Solanaceae)

Journal of the Brazilian Chemical Society

Nelissa Pacheco Vaz²  Emmanoel V. Costa²  Érica L. Santos²  Sandra Bos Mikich¹  Francisco A. Marques²  Raquel M. Braga¹  Camila Delarmelina¹  Marta C. T. Duarte¹  Ana Lúcia T. G. Ruiz¹  Vanessa H. S. Souza¹  João E. De Carvalho¹  Beatriz H. L. N. Sales Maia² 

[1] ,Universidade Federal do Paraná Departamento de Química Curitiba PR ,Brazil

关键词: Solanum caavurana;    Solanaceae;    caavuranamide;    steroidal alkaloids;    spirosolane;   

DOI  :  10.1590/S0103-50532012000200025

来源: SciELO

【 摘 要 】

Phytochemical investigation of the ripe fruits of Solanum caavurana Vell. (Solanaceae) afforded a novel steroidal alkaloid with spirosolane-type skeleton, named as caavuranamide, together with the alkaloids 4-tomatiden-3-one and 5α-tomatidan-3-one. Their structures were elucidated on the basis of spectroscopic methods. The antiproliferative and antimicrobial activities for the ethanolic extract, sub-fractions obtained from partition and acid-base treatment were also evaluated. Caavuranamide showed antibacterial activity similar to the chloramphenicol positive control against Rhodococcus equi.

【 授权许可】

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