Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans

Marine Drugs

Chun-Yan An¹  Xiao-Ming Li¹  Chun-Shun Li¹  Ming-Hui Wang¹  Gang-Ming Xu¹ 

[1] Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China; E-Mails:

关键词: mangrove;    endophytic fungus;    Aspergillus nidulans;    secondary metabolites;    bioactivity;   

DOI  :  10.3390/md11072682

来源: mdpi

【 摘 要 】

Four new quinazolinone alkaloids, namely, aniquinazolines A–D (1–4), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined on the basis of chiral HPLC analysis of the acidic hydrolysates. The structure for 1 was confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.