Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106

Marine Drugs

Jutta Wiese¹  Vanessa Oesker¹  Johannes F. Imhoff¹  Rolf Schmaljohann¹  Bin Wu¹ 

[1] Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel,Kiel 24105, Germany;

关键词: pyridones;    antibiotic;    Trichoderma;    marine fungus;   

DOI  :  10.3390/md12031208

来源: DOAJ

【 摘 要 】

Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization ofa pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively.

【 授权许可】

Unknown